Zebrafish as a model organism for blood diseases
نویسندگان
چکیده
منابع مشابه
Zebrafish as a new model organism for Parkinson’s disease
Parkinson’s Disease (PD) is the second most common human neurodegenerative disorder. PD patients present aberrant motor activity with resting tremor, muscular rigidity, bradykinesia and postural imbalance [1, 2]. The cause of these symptoms is loss of dopaminergic neurons in the substantia nigra, pars compacta. Another pathological hallmark of PD is the frequent formation of Lewy bodies in surv...
متن کاملCaenorhabditis Elegans as a Model Organism for Er-related Diseases
Endoplasmic reticulum (ER) is the site where nascent polypeptides fold and assemble into proteins that are secreted, targeted for expression at the plasma membrane or directed to intracellular organelles. Mutations in the ER machineries that perform the quality control, assemble the protein complexes, export or send misfolded proteins for degradation could trigger ER-related diseases. In this r...
متن کاملDrosophila melanogaster as a Model Organism of Brain Diseases
Drosophila melanogaster has been utilized to model human brain diseases. In most of these invertebrate transgenic models, some aspects of human disease are reproduced. Although investigation of rodent models has been of significant impact, invertebrate models offer a wide variety of experimental tools that can potentially address some of the outstanding questions underlying neurological disease...
متن کاملThe zebrafish: a new model organism for integrative physiology.
This brief review summarizes features of the zebrafish, Danio rerio, that make it a suitable model organism for studies of regulatory physiology. The review presents the argument that random mutagenesis screens are a valuable gene-finding strategy to identify genes of functional importance and that their utility, although well established for developmental issues, will extend to a variety of to...
متن کاملZebrafish as a Model Organism for the Development of Drugs for Skin Cancer
Skin cancer, which includes melanoma and squamous cell carcinoma, represents the most common type of cutaneous malignancy worldwide, and its incidence is expected to rise in the near future. This condition derives from acquired genetic dysregulation of signaling pathways involved in the proliferation and apoptosis of skin cells. The development of animal models has allowed a better understandin...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: British Journal of Haematology
سال: 2003
ISSN: 0007-1048
DOI: 10.1046/j.1365-2141.2003.04682.x